PENGARUH ANGKAK HASIL FERMENTASI BERAS OLEH Monascus purpureus JMBa TERHADAP AKTIVITAS ANTIOKSIDAN DAN GLUTATHION PEROKSIDASE (GPx) SERTA HISTOPATOLOGI HATI TIKUS GALUR SPRAGUE DAWLEY

Ernawati Kasim, Evi Triana, Titin Yulinery, Novik Nurhidayat
10.14203/beritabiologi.v11i2.487
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Abstract

Free radicals released from metabolism processes in the body were reactive and toxic to cells and tissues because it cause protein, cell membrane and nucleic acid damages which lead to cancer. It could be overcame if antioxidant system in the body is in good function.Nevertheles antioxidant system could be destructed by variety of conditions. Modern lifestyle that frequently consumed of high saturated fat, additives, and low fiber content in foods were potential risk for cancer and hypercholesterolemia. To overcome that risks with specific drugs were high cost. Therefore this research was conducted to take advantages of natural sources which potential for antioxidant and antihypercholesterolemia activities that could be fast, easy and inexpensive processing. One of the natural sources that meet the criteria was angkak resulted from rice fermented by Monascus purpureus. The result revealed that angkak contained lovastatin showed antioxidant and antihypercholesterolemia activities and increased glutathion peroxidase activity of optimal dose 5 g/day. The histopathologi observation of rat’s liver showed that administered of angkak on rats feed high level of cholesterol inhibited accumulation of fat in rat’s liver.

Keywords

Angkak, M. purpureus JMBa, antioksidan/antioxidant, glutation peroksidase/Glutathion peroxidase, histopathologi hati/liver histopatology.

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References

Anonim. 2006. Hypercholesterolemia. Penn State Milton S. Hershey Medical Center. Melalui: http://www.hmc.psu.edu/healthinfo/h/hypercholesterolemia.htm Diakses tanggal 02/09/11.

Anonim. 2008. Peran statin dalam global risk reduction, bukan sekedar penurun LDL. Farmacia 7(7), 58.

Asikin N. 2001. Antioksidan endogen dan penilaian status oksidan. Kursus penyegaran dan pelatihan radikal bebas dan antioksidan: Dasar aplikasi dan pemanfaatan bahan alam. Bagian Biokimia Fakultas Kedokteran Universitas Indonesia.

Brown MS dan JL Goldstein. 1991. Drugs Used in The Treatment of Hyperlipoprotein. The Pharmacological Basis of Therapeutics. Edisi ke-8. New York: McGraw Hill Book.

Dahlianti V. 2001. Ekstrak Jamur Kuping (Auricularia polytricha) sebagai antihiperlipidemia pada tikus putih galur Wistar. Skripsi. Institut Pertanian Bogor.

Dalimartha S. 2001. 36 Resep Tumbuhan Untuk Menurunkan Kolesterol. Cetakan ke-3. Penebar Swadaya. Jakarta.

Fridovich I. 1978. The biology of oxygen radicals. Science. 201,875-879 Halliwell B. 1997. Antioxidant characterization. Methodology and Mechanism Biochemistry Pharmacology 49, 1341–1348

Harris ED. 1992. Regulation of antioxidant enzymes. Faseb J. 6, 2675 – 2683 Heber D, I Yip and JM Ashley. 1999. Cholesterol-lowering effects of a proprietary chinese red-yeast-rice dietary supplement. Am. J. Clin. Nutr. 69, 231-236.

Heyne K. 1987. Monascaceae. Tumbuhan Berguna Indonesia. Jilid I. Badan Litbang Kehutanan. Jakarta. Kasim E, S Astuti and N Nurhidayat. 2005. Karakterisasi pigmendan kadar lovastatin beberapa isolat Monascus purpureus. Biodiversitas 6(4), 245-247.

Kasim E, Y Kurniawati and N Nurhidayat. 2006. Pemanfaatan isolat lokal Monascus purpureus untuk menurunkan kolesterol darah pada tikus putih galur Sprangue Dawley. Biodiversitas 7(2), 122-124.

King MW. 2007. Cholesterol and bile metabolism. Dalam: http://www.med.unibs.it/~marchesi/cholest.gif Diakses tanggal 02/09/08.

Kochhar SP dan JB Rossell. 1990. Detection, estimation and evaluation of antioxidants in food system. In: BJF Hudson (Ed.). Food Antioxidant, 19-64. Elsevier Applied Science, New York.

Kono H, S Iwakami and M Shibuya. 2001. Diphenyleneodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. http://www.ajpi.org

MacLachlan NJ and JM Cullen. 1995. Liver, Biliary System and Exocrine Pancreas. Thomson’s special veterinary pathology. 2nd ed, 81-114. Mosby, St. Louis.

Mates JM, PM Abuja and R Albertini. 1999. Antioxidant diseases. Clin Biochem. 32(8), 595-603.

McCord JM. 2000. The evolution of free radicals and axidative stress. The American Journal of Medicine. 108(8), 652-659

Pattanagul P, R Pinthong, A Phianmongkhol and N Leksawasdi. 2007. Review of angkak production (Monascus purpureus). Chiang Mai J Sci. 34(3), 318-328.

Siswandoro SB. 1997. Kimia Medicinal, Surabaya, Airlangga University Press Soleh S. 1996. Patologi. Edisi ke-1. Fakultas Kedokteran Universitas Indonesia.

Swierzewski SJ. 2000. High cholesterol. Melalui: http://www.cardiologychannel.com/hypercholesterolemia/index.shtml Diakses tanggal 02/09/08.

Takemoto M, K Node, H Nakagami, Y Liao, M Grimm, Y Takemoto, M Kitakaze and JK Liao. 2001. Statin as antioxidant therapy for preventing cardiac myocytehypertrophy. J. Clin. Invest. 100, 1429-1437.

Young IS and JV Woodside. 2001. Antioxidants in health and disease. J Clin Pathol. 54: 176-724

Zaltzberg H, Y Kanter, M Aviram and Y Levy 1999. Increased plasma oxidizability and decreased erythrocyte and plasma antioxidative capacity in patients with NIDDM.Isr. Med. Assoc. J. 1, 228–231.

Zhou Z, D Zhenwen and X Shenmeng. 2002. Study of Xuezhikang Chinese New Drugs Journal http://www.wpu.com.on/English/e-3.htm

DOI: https://doi.org/10.14203/beritabiologi.v11i2.487

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